Mechanisms of Iron Absorption and Transport in Neonatal Rat Intestine
نویسندگان
چکیده
منابع مشابه
Mucosal iron transport by rat intestine.
Using highly sensitive 2-site immunoradiometric assays, we examined the relationship between iron absorption from closed intestinal loops and transferrin and ferritin concentrations in isolated duodenal mucosal cells. As in prior studies, mucosal ferritin correlates inversely with iron absorption and directly with body iron stores as measured by the concentration of nonheme iron in liver. Mucos...
متن کاملElevated iron absorption in the neonatal rat reflects high expression of iron transport genes in the distal alimentary tract.
Intestinal iron absorption is extremely high in neonatal mammals but falls rapidly to adult levels following weaning. The aim of this study was to investigate the molecular basis of this elevated neonatal absorption using the rat as an experimental model. RNA was extracted from various sections of the intestine of 10-, 15-, 20-, 25-, and 300-day-old rats and the expression of the genes encoding...
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To define the iron absorptive phase across the intestinal mucosa of neonatal pigs, the final SgFe concentration ratio of serosal to mucosal medium of everted gut sac at 1 hr incubation was measured. With .2 btg carrier iron (ferric citrate with molecular weight of 1,500) per milliliter of both the serosal and mucosal medium, the duodenum transported the iron against the concentration gradient f...
متن کاملStructural and functional analysis of glucose absorption mechanisms in the rat small intestine in vivo.
The absorption of glucose (free, and released from membrane hydrolysis of maltose) and water in the isolated loop of the rat small intestine was studied in chronic experiments. Even at maximum glucose (75 mmol/l) or maltose (37.5 mmol/l) concentrations the rate of glucose transfer by solvent drag and by diffusion did not exceed 13% and 25%, respectively, of the total rate of glucose absorption....
متن کاملSMALL INTESTINE Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat
Background: Iron absorption increases during pregnancy to cater for the increased iron requirements of the growing fetus. Aims: To investigate the role of the duodenal iron transport molecules and hepatic regulatory molecules in coordinating the changes in iron absorption observed during pregnancy. Methods: Rats at various days of gestation and 24–48 hours post-partum were examined for hepatic ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1973
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(73)80167-2